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KMID : 0606320040210010001
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Journal of Phamacetical Sciences Sookmyung Women s University
2004 Volume.21 No. 1 p.1 ~ p.8
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Pharmacological Activities of Extract and Constituents from Gardenia jasminoides
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Koo Hye-Jin
Park Eun-Hee
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Abstract
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Gradenia has been traditionally used as a folk medicine for centuries in Oriental countries. Its ethanolic extract (GFE) and two known constituents, genipin and geniposide, were used to elucidate its pharmacological actions. GFE, genipin and geniposide showed anti-inflammatory effects in rat paw edema test. Both genipin and geniposide contained inhibitory activites on production of exudate and nitric oxide (N0) in rat air-pouch edema model, whereas GFE inhibited the production of exudate. GFE showed inhibitory effects on acetic acid-induced vascular permeability and writhing in mice. Genipin showed antioxidant activity in lipid peroxidation (LPO) assay using rat brain homogenate. In summary, the results support anti-inflammatory and related activities of gardenia.
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